August 2, 2025Open Access

Stress-dependent growth of breast cancer models emerges from a cellular volume checkpoint

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Biophysical model reveals cell growth in breast cancer spheroids is influenced by osmolarity and biomechanical feedback.

The model shows that breast cancer spheroids grow in response to environmental stress, suggesting a volume checkpoint exists during mitosis.
High hydrostatic forces from extracellular loading can restrict cell growth, indicating a competition with osmotic pressure from biomolecule synthesis.
The research integrates biophysical modeling with experimental validations using a neural-network-accelerated finite element solver.
Findings provide a new understanding of mechanosensitive growth arrest, which may be applicable to various biological tissues beyond cancer.

Senthilkumar et al. (2025) studied this question.

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