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March 12, 2026Mechanics Of Soft MaterialsOpen Access

Feedback between proliferation, intercalation, and growth mechanics in multicellular aggregates

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Authors

PBPrakhar BandilFVFranck J. Vernerey

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Overview

Examines the relationships between growth mechanics and cellular processes in multicellular structures, suggesting new insights for engineering applications.

Key Points

  • The aim is to explore how growth mechanics interact with cellular activities like division and intercalation in multicellular aggregates.
  • Utilized a continuum theory of morpho-viscoelasticity for modeling growth.
  • Implemented numerical simulations within a finite element framework.
  • Investigated feedback mechanisms affecting spheroid growth dynamics.
  • Cell size homeostasis significantly regulates stress and morphology in aggregates.
  • Cellular reorganization through intercalation contributes to stress relaxation.
  • Mechanistic insights from the study enhance understanding for engineering spheroids and organoids.

Cite This Study

Bandil et al. (2026) studied this question.

synapsesocial.com/papers/69b2579096eeacc4fcec64ebhttps://doi.org/10.1007/s42558-026-00071-4
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