Supplementary Data 3 from Unraveling the Tumor Microenvironment and PD-L1 Expression across Tissue Types in High-Grade Serous Ovarian Cancer in the NeoPembrOV/GINECO Phase II Randomized Trial

Key Points

MAIN FINDING: The research demonstrates significant correlation between cd274 expression and gene sets in high-grade serous ovarian cancer.
KEY EVIDENCE: Analysis of data from the NeoPembrOV and Australian Ovarian Cancer Study reveals distinct expression patterns related to PD-L1.
APPROACH: This study utilized data from a Phase II randomized trial to examine the tumor microenvironment and genetic factors.
SIGNIFICANCE: Findings highlight potential targets for immunotherapy in ovarian cancer, impacting treatment strategies and outcomes.

Randomized trial uncovers the correlation between cd274 and gene sets in high-grade serous ovarian cancer, suggesting implications for treatment.

Supplementary Data 3. Correlation between CD274 and hallmarks gene sets in NeoPembrOv and Australian Ovarian Cancer Study (AOCS).

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Collet et al. (2025) studied this question.

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