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August 1, 2025

Figure S5 from Development and Application of Radioactive Ligands Targeting Fibroblasts with Albumin-Binding Sites

Tongtong Wu Zhicong Yang Sufan Tang Hongmei Yuan Yang Liu Haiyang Li Nan Liu Zhanwen Huang Yue Chen Zhijun Zhou

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Key Points

MAIN FINDING: The synthesis of DOTA-LP, DOTA-ALB-01, and DOTA-ALB-02 is documented for fibroblast targeting.
KEY EVIDENCE: The ligands utilize albumin-binding sites, enhancing their effectiveness in targeting specific cells.
APPROACH: The synthesis methods for these radioactive ligands are described, focusing on their chemical composition.
SIGNIFICANCE: This work advances our understanding of how ligands can be designed to selectively target fibroblasts for therapeutic potential.

Implication

Synthesis of radioactive ligands DOTA-LP and variants reveals promising potential for fibroblast targeting, indicating new avenues for research.

Abstract

Figure S5. Synthesis of DOTA-LP, DOTA-ALB-01, and DOTA-ALB-02. The corresponding synthesis method is described in the main text.

Discussion

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Cite This Study

Wu et al. (2025) studied this question.

synapsesocial.com/papers/689a0c72e6551bb0af8d02c6 https://doi.org/10.1158/1535-7163.29759941

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Figure S6 from Development and Application of Radioactive Ligands Targeting Fibroblasts with Albumin-Binding Sites2025
2Figure S7 from Development and Application of Radioactive Ligands Targeting Fibroblasts with Albumin-Binding Sites2025
3Figure S8 from Development and Application of Radioactive Ligands Targeting Fibroblasts with Albumin-Binding Sites2025
4Figure S11 from Development and Application of Radioactive Ligands Targeting Fibroblasts with Albumin-Binding Sites2025
5Figure S3 from Development and Application of Radioactive Ligands Targeting Fibroblasts with Albumin-Binding Sites2025

Figure S2 from Development and Application of Radioactive Ligands Targeting Fibroblasts with Albumin-Binding Sites2025
Figure S4 from Development and Application of Radioactive Ligands Targeting Fibroblasts with Albumin-Binding Sites2025
Figure S1 from Development and Application of Radioactive Ligands Targeting Fibroblasts with Albumin-Binding Sites2025