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August 1, 2025

Figure S11 from Development and Application of Radioactive Ligands Targeting Fibroblasts with Albumin-Binding Sites

Tongtong Wu Zhicong Yang Sufan Tang Hongmei Yuan Yang Liu Haiyang Li Nan Liu Zhanwen Huang Yue Chen Zhijun Zhou

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Key Points

The core finding indicates that the 68Ga-DOTA ligands effectively target fibroblasts in vivo.
Specificity was demonstrated for multiple ligands, including 68Ga-DOTA-ALB-01 and 68Ga-DOTA-ALB-02.
In vivo studies were performed to examine the blocking capabilities of the ligands 1 hour post-injection.
These radioactive ligands could advance the field of targeted therapies by providing a new mechanism for fibroblast imaging and treatment.

Implication

In vivo evaluation of 68Ga-DOTA ligands shows specificity for fibroblasts, highlighting their potential applications.

Abstract

Figure S11. in vivo blocking and specificity of 68Ga-DOTA-LP (A), 68Ga-DOTA-ALB-01 (B),68Ga-DOTA-ALB-02 (C), and68Ga-DOTA-ALB-03 at 1 h p.i.

Discussion

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Cite This Study

Wu et al. (2025) studied this question.

synapsesocial.com/papers/689a0c72e6551bb0af8d02f6 https://doi.org/10.1158/1535-7163.29759968

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Figure S7 from Development and Application of Radioactive Ligands Targeting Fibroblasts with Albumin-Binding Sites2025
2Figure S8 from Development and Application of Radioactive Ligands Targeting Fibroblasts with Albumin-Binding Sites2025
3Figure S5 from Development and Application of Radioactive Ligands Targeting Fibroblasts with Albumin-Binding Sites2025
4Figure S13 from Development and Application of Radioactive Ligands Targeting Fibroblasts with Albumin-Binding Sites2025
5Figure S6 from Development and Application of Radioactive Ligands Targeting Fibroblasts with Albumin-Binding Sites2025

Table S1 from Development and Application of Radioactive Ligands Targeting Fibroblasts with Albumin-Binding Sites2025
Figure S12 from Development and Application of Radioactive Ligands Targeting Fibroblasts with Albumin-Binding Sites2025
Table S6 from Development and Application of Radioactive Ligands Targeting Fibroblasts with Albumin-Binding Sites2025