Figure S13 from Development and Application of Radioactive Ligands Targeting Fibroblasts with Albumin-Binding Sites

Tongtong Wu; Zhicong Yang; Sufan Tang; Hongmei Yuan; Yang Liu; Haiyang Li; Nan Liu; Zhanwen Huang; Yue Chen; Zhijun Zhou

doi:10.1158/1535-7163.29759959

August 1, 2025

Figure S13 from Development and Application of Radioactive Ligands Targeting Fibroblasts with Albumin-Binding Sites

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Key Points

Micro-SPECT/CT imaging shows the distribution of 177Lu-labeled ligands in tumors of U87MG mice.
After 1 hour, significant accumulation of 177Lu-FAPI-46 is observed in tumor regions.
Imaging was performed at 1 and 4 hours post-injection of radioactive ligands in mice.
These findings may enhance targeting strategies for therapies using albumin-binding sites.

Implication

Micro-SPECT/CT imaging reveals the distribution of radioactive ligands in tumors, suggesting insights into albumin-binding sites.

Abstract

Figure S13. Micro-SPECT/CT imaging of 177Lu-FAPI-46, 177Lu-DOTA-LP, and 177Lu-DOTA-ALB-03 in U87MG tumor-bearing mice at 1, 4 h (tumors are marked with white arrows).

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Cite This Study

Wu et al. (2025) studied this question.

synapsesocial.com/papers/689a0c72e6551bb0af8d02bf https://doi.org/10.1158/1535-7163.29759959

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Figure S13 from Development and Application of Radioactive Ligands Targeting Fibroblasts with Albumin-Binding Sites

Key Points

Implication

Abstract

Discussion

Cite This Study

Figure S13 from Development and Application of Radioactive Ligands Targeting Fibroblasts with Albumin-Binding Sites

Key Points

Implication

Abstract

Discussion

Cite This Study

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