Experiments reveal TCR-based therapy is safe and effective in treating prostate cancer, highlighting key gene expressions.
Boxplots depicting (A) CDH23 and (B) LOXHD1 expression in various tumor types (TCGA data n=30) and healthy tissue types (TCGA data n=30 and GTEx data n=5-20). Red, green and white boxplots represent tumor types (TCGA data), healthy tissues (TCGA data), and healthy tissues (GTEx), respectively. Boxplots extend from first to third quartile, the horizontal line represent the median expression value. The whiskers represent the minimum and maximum expression value (1.5 IQR from the first and third quartile). Outliers are defined as being 1.5*IQR or more above the third or below the first quartile, respectively. Y-axis abbreviations are described in supplemental table 1. (FC: fold change, GTEx: genotype-tissue expression, IQR: interquartile range, log2-CPM: log2-transformed counts per million, TCGA: The cancer genome atlas)
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Amerongen et al. (2025) studied this question.
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