Supplemental Figure 7 from TCR-Based Therapy Directed against Kallikrein-Related Peptidase 4 Is Safe and Effective against Prostate Cancer

IFN-ƴ production (ng/mL) of the TCR-T cells cocultured overnight with peptide-loaded (500 nM) prostate tumor cell lines (E:T=1:6). (A) KLK4-A2 (23.1A6) TCR-T cells and CMV TCR-T cells stimulated with HLA-A2+ prostate tumor cell lines, (B) KLK3-B35 (36.2.2E3) TCR-T cells and CMV TCR-T cells stimulated with HLA-B35+ prostate tumor cell lines. Bars represent mean and symbols depict averaged duplicate values from two different donors. Experiments were performed simultaneously with the experiments shown in Figure 4B, and symbols of the two donors match. (E:T: effector:target ratio)