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August 2, 2025Open Access

The ten dollar proteome: low-cost, deep and quantitative proteome profiling of limited sample amounts using the Orbitrap Astral and timsTOF Ultra 2 mass spectrometers

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Authors

SHSiqi HuangCWChao WangHLHsien‐Jung L. Lin

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Overview

Analytical framework achieves $10 per sample proteome profiling in limited samples, indicating potential for broad use in research.

Key Points

  • The $10 proteome framework allows for quantitative proteome profiling at significantly reduced costs.
  • Using Orbitrap Astral and timsTOF Ultra 2 mass spectrometers, up to 8000 protein groups can be quantified from as little as 10 ng of input.
  • Analysis demonstrates effective sample preparation workflows suitable for low input amounts, enhancing access to proteomics.
  • This innovation supports scalable applications in systems biology and clinical research, making advanced proteomics more accessible.

Cite This Study

Huang et al. (2025) studied this question.

synapsesocial.com/papers/689a0c72e6551bb0af8d034bhttps://doi.org/10.1101/2025.07.29.667408
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The One Hour Human Proteome2024 · 56 citations
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  4. 4B-146 Unlocking the potential of large-cohort proteomics studies with the Orbitrap Astral mass platform2024 · 1 citations
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