August 2, 2025Frontiers in OncologyOpen Access

Extensive thoracic vertebral and chest wall metastases as the initial presentation of breast cancer: a case report and literature review

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Discussion

Case report reveals thoracic vertebral metastases as initial symptom in breast cancer, highlighting diagnostic challenges.

Metastatic involvement of the thoracic skeleton can be the first sign of an undiagnosed breast cancer.
A 60-year-old woman experienced severe thoracic pain, leading to imaging that detected multiple lytic lesions.
A percutaneous vertebral biopsy confirmed undifferentiated carcinoma after imaging identified active breast lesions.
This case emphasizes the need for high oncologic suspicion and advanced imaging to ensure timely diagnosis and treatment.

Kenzhegulov et al. (2025) studied this question.

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