Identification, functional analysis, and clinical applications of defective viral genomes

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Discussion

Systematic review demonstrates clinical applications of defective viral genomes in antiviral therapy, indicating potential for novel vaccine design.

DVGs are important in regulating viral replication and host immune responses.
Advances in high-throughput sequencing improved identification of DIPs and DVGs.
Both DIPs and DVGs inhibit viral proliferation by competing for replication resources.
DIPs and DVGs show promise for novel vaccine design and broad-spectrum antiviral therapies.

Yan et al. (2025) studied this question.

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Systematic review demonstrates clinical applications of defective viral genomes in antiviral therapy, indicating potential for novel vaccine design.