Key result
Defective viral genomes play a critical role in both acute and long-term virus-host interactions through their immunostimulatory and pro-persistence activities.
Design
Review
Authors
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May inform antiviral strategies against persistence; leaves open clinical translation pending prospective validation.
This review summarizes the molecular intersection between the immunostimulatory and pro-persistence activities of defective viral genomes.
Manzoni et al. (2018) conducted a review in Viral infections (Ebola, dengue, respiratory syncytial virus). Defective viral genomes (DVGs) was evaluated. Defective viral genomes play a critical role in both acute and long-term virus-host interactions through their immunostimulatory and pro-persistence activities.
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