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August 2, 2025Frontiers in ImmunologyOpen Access

Macrophages in chronic infections: regulation and remodeling

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Authors

HCHongle CuiMWMin WangSJShunchang Jiao

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Overview

Review discusses how macrophages modulate their functions via metabolic pathways in chronic infections, highlighting immune evasion implications.

Key Points

  • Macrophages play a crucial role in responding to infections by adapting their metabolic pathways.
  • Pathogens can exploit macrophage plasticity to evade the immune response, leading to chronic infections.
  • The review highlights the relationship between macrophage polarization and their metabolic reprogramming.
  • Understanding macrophage metabolism may reveal new avenues for enhancing trained immunity during chronic infections.

Cite This Study

Cui et al. (2025) studied this question.

synapsesocial.com/papers/689a0c72e6551bb0af8d0475https://doi.org/10.3389/fimmu.2025.1594988
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Also Consider

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  5. 5Macrophages in the crossfire of sepsis: deciphering immunometabolic reprogramming, autophagy, and novel immunomodulatory therapeutic strategies2026