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August 2, 2025Frontiers in ImmunologyOpen Access

Kawasaki disease: insights into the roles of T cells

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Authors

SWShuhui WangYunnan Agricultural UniversityGQGuanghui QianZhejiang A & F UniversityYLYing LiuShangrao Normal University

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Implication

This review highlights T cell involvement in inflammation and IVIG resistance in Kawasaki disease, suggesting novel therapeutic targets.

Key Points

  • Kawasaki disease is an immune vasculitis that primarily affects children, causing significant cardiovascular risks.
  • Abnormal activation of T cells, particularly expansion of CD8+ T cells, contributes to persistent inflammation in Kawasaki disease.
  • Imbalance between Th17 and Tregs is linked to IVIG resistance, complicating treatment strategies for Kawasaki disease.
  • Targeting T cell function with immunomodulatory therapies may improve clinical outcomes and provide new insights into Kawasaki disease management.

Cite This Study

Wang et al. (2025) studied this question.

synapsesocial.com/papers/689a0c7be6551bb0af8d0499https://doi.org/10.3389/fimmu.2025.1582638
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Diagnosis, Treatment, and Long-Term Management of Kawasaki Disease: A Scientific Statement for Health Professionals From the American Heart Association2017 · 3,819 citations
  2. 2Allograft Inflammatory Factor-1 Links T-Cell Activation, Interferon Response, and Macrophage Activation in Chronic Kawasaki Disease Arteritis2017 · 20 citations
  3. 3Understanding the Pathogenesis of Kawasaki Disease by Network and Pathway Analysis2013 · 41 citations
  4. 4Regulatory T cell microRNA expression changes in children with acute Kawasaki disease2014 · 68 citations
  5. 5Characterization of circulating immune cells in acute Kawasaki disease suggests exposure to different antigens2020 · 23 citations