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July 1, 1997The Journal of Immunology

Clonal expansion of CD8+ T cells in Kawasaki disease

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Population

Patients with Kawasaki disease (evaluated during acute, subacute, and long-term follow-up periods)

Design

Other

Follow-up

long term

Authors

ICIn‐Hong ChoiChonnam National UniversityYCY J ChwaeNational Institutes of HealthWSWinston ShimSingapore Institute of Technology

Discussion

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Implication

Challenges superantigen model of Kawasaki disease; hypothesis-generating for antigen-specific CD8 responses.

Structured PICO

P
Population
Patients with Kawasaki disease (evaluated during acute, subacute, and long-term follow-up periods)
O
Outcome
Clonal expansion of T cells (complementarity-determining region 3 size profile among T cells expressing specific TCRBV chains)surrogate

Clonal expansion of CD8+ T cells during acute Kawasaki disease suggests the involvement of conventional antigens rather than superantigens in its pathogenesis.

Cite This Study

Choi et al. (1997) studied this question.

synapsesocial.com/papers/6a85b1dcb451cea71dae7608https://doi.org/10.4049/jimmunol.159.1.481
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Kawasaki disease: insights into the roles of T cells2025 · 10 citations
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  4. 4Polymorphism-driven immune disruptions in Kawasaki disease across populations: decoding the role of T and B-cells2025 · 3 citations
  5. 5Delineation of Single-cell Altas Provides New Insights for Development of Coronary Artery Lesions in Kawasaki Disease: Bad and Good Signaling Molecules2024