August 4, 2025

Supplementary Figure 12 from Defining the Ovarian Cancer Precancerous Landscape through Modeling Fallopian Tube Epithelium Reprogramming Driven by Extracellular Vesicles

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Modeling identifies key pathways influenced by extracellular vesicles from OVCAR3 in ovarian cancer.
Both upregulation and downregulation of specific pathways were noted in the examined epithelium.
Extracellular vesicles play a critical role in the reprogramming of fallopian tube epithelium.
Understanding these processes may aid in early detection and prevention of ovarian cancer.

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Modeling reveals pathways altered by OVCAR3 extracellular vesicles in fallopian tube epithelium, indicating potential precancerous changes.

KEGG and reactome pathways upregulated and downregulated by OVCAR3 EVs.

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Sipes et al. (2025) studied this question.

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Modeling reveals pathways altered by OVCAR3 extracellular vesicles in fallopian tube epithelium, indicating potential precancerous changes.

KEGG and reactome pathways upregulated and downregulated by OVCAR3 EVs.