August 4, 2025

Supplementary Figure 13 from Defining the Ovarian Cancer Precancerous Landscape through Modeling Fallopian Tube Epithelium Reprogramming Driven by Extracellular Vesicles

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MAIN FINDING: Upregulation and downregulation of pathways are linked to the action of FT240 extracellular vesicles.
KEY EVIDENCE: Specific kegg and reactome pathways were altered, indicating the impact of extracellular vesicles on the fallopian tube epithelium.
APPROACH: The study utilized models to assess how FT240 extracellular vesicles influence the cellular environment.
SIGNIFICANCE: Understanding these pathways enhances knowledge of ovarian cancer precursors that develop from fallopian tube epithelium.

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Modeling shows changes in kegg and reactome pathways in fallopian tube epithelium driven by extracellular vesicles.

Kegg and reactome pathways upregulated and downregulated by FT240 EVs.

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Sipes et al. (2025) studied this question.

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Modeling shows changes in kegg and reactome pathways in fallopian tube epithelium driven by extracellular vesicles.

Kegg and reactome pathways upregulated and downregulated by FT240 EVs.