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August 4, 2025European Journal of Applied PhysiologyOpen Access

Physical exercise in metabolic myopathies at risk of rhabdomyolysis: a feasible approach or an unavoidable hazard?

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Authors

OCOscar CrisafulliDDDaniele DiottiMNMassimo Negro

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Overview

Review examines physical exercise risks in metabolic myopathies, suggesting tailored interventions could mitigate rhabdomyolysis risks.

Key Points

  • MAIN FINDING: Metabolic myopathies pose significant exercise-related risks, especially rhabdomyolysis, requiring careful management.
  • KEY EVIDENCE: While inactivity helps avoid rhabdomyolysis, it can lead to reduced physical function and other long-term health issues.
  • APPROACH: This review analyzes the feasibility of physical exercise in glycogen storage diseases and fatty acid oxidation disorders.
  • SIGNIFICANCE: Identifying safe exercise modalities is essential for improving quality of life in patients with these rare conditions.

Cite This Study

Crisafulli et al. (2025) studied this question.

synapsesocial.com/papers/689a0f93e6551bb0af8d0ff6https://doi.org/10.1007/s00421-025-05922-y
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