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July 23, 2018Current Opinion in Neurology

Exercise in muscle disorders: what is our current state?

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Key result

Exercise is generally safe and improves functional outcomes in patients with inherited muscle disease, though prescriptions should be disease specific.

Why the study?

Does exercise improve functional outcomes and is it safe in patients with inherited myopathy?

Population

Humans with inherited myopathy

Design

Review

Authors

NPNicolai PreislerUniversity of CopenhagenMØMette Cathrine ØrngreenCopenhagen University Hospital

Discussion

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Implication

May warrant caution prescribing exercise in dysferlinopathy; observational data leave open causality and need prospective trials.

Structured PICO

Does exercise improve functional outcomes and is it safe in patients with inherited myopathy?

P
Population
Humans with inherited myopathy
I
Intervention
Exercise (including high intensity exercise, exoskeletons, and antigravity trainers)
O
Outcome
Functional outcomes and safetypatient reported

Exercise is generally safe and improves functional outcomes in inherited myopathies, but prescriptions must be tailored to the specific disease.

Cite This Study

Preisler et al. (2018) conducted a review in inherited myopathy. Exercise was evaluated. Exercise is generally safe and improves functional outcomes in patients with inherited muscle disease, though prescriptions should be disease specific.

synapsesocial.com/papers/6ab4802e1f2d3082cbf638cchttps://doi.org/10.1097/wco.0000000000000597
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Cellular and molecular mechanisms underlying muscular dystrophy2013 · 242 citations
  2. 2The Effect of Exercise in Muscular Dystrophy1966 · 136 citations
  3. 3Physical Activity in Boys With Duchenne Muscular Dystrophy Is Lower and Less Demanding Compared to Healthy Boys2017 · 41 citations
  4. 4Teenage exercise is associated with earlier symptom onset in dysferlinopathy: a retrospective cohort study2018 · 26 citations