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August 5, 2025

Linc01232 regulates mir-516a-5p/bcl9 axis to promote triple-negative breast cancer progression

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Authors

WLWei LiuYNYunfeng NiuJAJie An

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Overview

Research demonstrates LINC01232 enhances migration and invasion in triple-negative breast cancer, indicating its role in the miR-516a-5p/BCL9 axis.

Key Points

  • LINC01232 is overexpressed in triple-negative breast cancer tissues compared to normal tissues.
  • Silencing LINC01232 significantly reduces cell proliferation, migration, and invasion in breast cancer cells.
  • LINC01232 competes with miR-516a-5p, decreasing its expression and increasing BCL9 levels.
  • These findings highlight LINC01232 as a potential therapeutic target in managing TNBC progression.

Cite This Study

Liu et al. (2025) studied this question.

synapsesocial.com/papers/689a0f93e6551bb0af8d12afhttps://doi.org/10.21203/rs.3.rs-7167048/v1
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