August 6, 2025Open Access

Multi-modal integration of protein interactomes with genomic and molecular data discovers distinct RA endotypes

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Network-based GWAS reveals genetic differences between CCP+ and CCP- rheumatoid arthritis endotypes, highlighting molecular heterogeneity.

Main finding reveals distinct genetic differences in rheumatoid arthritis based on anti-cyclic citrullinated peptide antibody status.
Utilizing the RACER cohort, significant heritability differences between CCP+ and CCP- RA patients were uncovered.
The network-based GWAS identified 14 gene modules explaining variations in antibody prevalence in rheumatoid arthritis.
These findings advance understanding of molecular heterogeneity and treatment responses in rheumatoid arthritis.

Rahimikollu et al. (2025) studied this question.

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Network-based GWAS reveals genetic differences between CCP+ and CCP- rheumatoid arthritis endotypes, highlighting molecular heterogeneity.