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August 6, 2025Open Access

Telomeres control human telomerase (hTERT) expression through non-telomeric TRF2

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Authors

ASAntara SenguptaSVSoujanya VinayagamurthyDSDrishti Soni

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Overview

Research reveals telomere length influences hTERT expression in various cancers, suggesting potential therapies.

Key Points

  • hTERT expression is controlled by telomere length, showing transcriptional changes based on telomere status.
  • Non-telomeric TRF2 interacts with the hTERT promoter and is crucial for regulating gene expression via repressor histone modifications.
  • Cell line experiments demonstrate that telomere elongation increases hTERT levels, while shortening decreases it in various cancer types.
  • Findings have significant implications for understanding telomere-related conditions, including cancer, ageing, and stem cell biology.

Cite This Study

Sengupta et al. (2025) studied this question.

synapsesocial.com/papers/689a0fa0e6551bb0af8d185dhttps://doi.org/10.7554/elife.104045.2
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Extra-telomeric impact of telomeres: Emerging molecular connections in pluripotency or stemness2020 · 21 citations
  2. 2Overexpression of Telomerase Confers Growth Advantage, Stress Resistance, and Enhanced Differentiation of ESCs Toward the Hematopoietic Lineage2005 · 156 citations
  3. 3Telomeres and telomerase in cancer2009 · 820 citations
  4. 4Activation of mutant <i>TERT</i> promoter by RAS-ERK signaling is a key step in malignant progression of BRAF-mutant human melanomas2016 · 107 citations