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October 1, 2025eLifeOpen Access

Telomeres control human telomerase (TERT) expression through non-telomeric TRF2

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Authors

ASAntara SenguptaInstitute of Genomics and Integrative BiologySVSoujanya VinayagamurthyInstitute of Genomics and Integrative BiologyDSDristhi SoniInstitute of Genomics and Integrative Biology

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Overview

Study demonstrates telomere length influences TERT expression in various cancer cell lines, highlighting potential implications for cancer and pluripotency.

Key Points

  • TERT expression is regulated by telomere length, demonstrating the influence of telomeres.
  • The binding of TRF2 to the TERT promoter varies with telomere length, impacting transcriptional activity.
  • Cell lines showed increased TERT with elongated telomeres, while shortened telomeres decreased TERT expression.
  • The regulation mechanism of TERT by TL could have significant implications for cancer, aging, and stem cell biology.

Cite This Study

Sengupta et al. (2025) studied this question.

synapsesocial.com/papers/68dd91d5fe798ba2fc498e42https://doi.org/10.7554/elife.104045.3
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Telomeres control human telomerase (hTERT) expression through non-telomeric TRF22025
  2. 2Pan-cancer experimental characteristic of human transcriptional patterns connected with telomerase reverse transcriptase (TERT) gene expression status2024 · 3 citations
  3. 3Regulation and Effects of Modulation of Telomerase Reverse Transcriptase Expression in Primordial Germ Cells During Development12006 · 22 citations
  4. 4Cross species activity of TERT human telomerase component2026
  5. 5Abstract 6144: A polymorphic <i>TERT</i> tandem repeat creating an expandable intronic G4 quadruplex is associated with <i>TERT</i> expression, relative leukocyte telomere length and cancer risk2024