Vitamin C as a Cardioprotective Agent Against Doxorubicin‐Induced Cardiotoxicity

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Review reveals vitamin C may reduce cardiotoxicity in patients receiving doxorubicin, suggesting potential benefits for cardiac health.

Vitamin C has shown potential as a cardioprotective agent against doxorubicin-induced cardiotoxicity.
Preclinical studies indicate that vitamin C can reduce oxidative stress and preserve mitochondrial function.
Animal models have demonstrated that vitamin C maintains cardiomyocyte structural integrity during treatment.
Clinical evidence for vitamin C's efficacy as an adjunct therapy during anthracycline therapy is emerging, although variable.

Nsairat et al. (2025) studied this question.

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