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September 10, 2025International Journal of Newgen Research in Pharmacy & Healthcare

Doxorubicin-Induced Cardiomyopathy: Molecular Mechanisms and Emerging Therapeutic Strategies

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Authors

MTMahewish TarannumRGRadha GoelRKRajeev Kumar

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Overview

Review highlights doxorubicin's cardiotoxicity and identifies potential therapeutic strategies for cardiomyopathy.

Key Points

  • Doxorubicin-induced cardiomyopathy significantly limits cancer treatment efficacy due to dose-dependent cardiotoxicity.
  • Key mechanisms include oxidative stress, mitochondrial dysfunction, and disruption of calcium homeostasis, exacerbating cardiac dysfunction.
  • Recent research identifies promising therapeutic targets and strategies, like mitochondrial stabilizers and natural antioxidants.
  • Advancements in targeted drug delivery and repurposing cardiovascular drugs may help mitigate cardiac injury from doxorubicin.

Cite This Study

Tarannum et al. (2025) studied this question.

synapsesocial.com/papers/68c1ad4f54b1d3bfb60e4d47https://doi.org/10.61554/ijnrph.v3i1.2025.146
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Molecular mechanisms, risk factors, and emerging cardioprotective strategies in doxorubicin-induced cardiotoxicity: a narrative review2026
  2. 2Doxorubicin‐Induced Cardiotoxicity: Comprehensive Pathway Insights and Advanced Preclinical Therapeutics2026 · 8 citations
  3. 3Alteration of cardiac energetics and mitochondrial function in doxorubicin‑induced cardiotoxicity: Molecular mechanism and prospective implications (Review)2025 · 17 citations
  4. 4Understanding Cardiomyopathy Induced by Doxorubicin Therapy: Mechanisms, Diagnosis, and Management Strategies2024
  5. 5Mechanisms and Drug Intervention for Doxorubicin‐Induced Cardiotoxicity Based on Mitochondrial Bioenergetics2022 · 41 citations