Key result
Doxorubicin induces cardiotoxicity via multiple regulated cell death pathways and myocardial dysfunction.
Why the study?
Anthracyclines are extremely cardiotoxic, but the precise mechanisms by which doxorubicin causes cardiomyocyte death and myocardial dysfunction remain incompletely understood.
Design
Review
Authors
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May inform targeted cardioprotective strategies in doxorubicin recipients; leaves open clinical validation of pathway-specific interventions.
Understanding the diverse regulated cell death pathways and dysfunction mechanisms in doxorubicin cardiotoxicity is crucial for developing targeted cardioprotective therapies.
Wang et al. (2023) conducted a review in Doxorubicin-induced cardiotoxicity. Doxorubicin was evaluated. Doxorubicin induces cardiotoxicity through multiple mechanisms of regulated cell death, including apoptosis, autophagy, ferroptosis, necroptosis, and pyroptosis, as well as myocardial dysfunction.
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