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January 1, 2022Oxidative Medicine and Cellular LongevityOpen Access

Mechanisms and Drug Intervention for Doxorubicin‐Induced Cardiotoxicity Based on Mitochondrial Bioenergetics

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Key result

This review summarizes the mechanisms of doxorubicin-induced cardiac mitochondrial bioenergetics disorders and potential interventions using chemical drugs and traditional herbal medicine.

Why the study?

Doxorubicin-induced cardiovascular disease is a primary cause of mortality in cancer survivors, with cardiac mitochondrial bioenergetics changes serving as a significant marker.

Design

Review

Authors

GLGuanjing LingXWXiaoping WangNTNannan Tan

Discussion

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Overview

Mitochondrial bioenergetics merit monitoring in DOX recipients; extends mechanistic understanding but leaves open targeted interventions.

Key Points

  • Summarize recent insights into the mechanisms of doxorubicin-induced cardiac mitochondrial bioenergetics disruption and evaluate potential chemical and herbal interventions.
  • Synthesized recent biomedical literature evaluating doxorubicin-induced cardiotoxicity mechanisms focused on mitochondrial energy pathways.
  • Reviewed experimental evidence for synthetic pharmaceuticals and traditional herbal medicines that target mitochondrial dysfunction to preserve cardiac function.
  • Doxorubicin impairs cardiac energy balance by disrupting mitochondrial substrate metabolism, damaging the respiratory chain, and diminishing myocardial ATP storage and utilization.
  • Targeted cardioprotective chemical compounds and herbal formulations attenuate cardiotoxicity by preserving mitochondrial integrity and restoring physiological energy production.

Structured PICO

P
Population
Models and patients with doxorubicin-induced cardiotoxicity (DIC)
I
Intervention
Chemical drugs and traditional herbal medicine targeting mitochondrial bioenergetics

This review highlights the role of mitochondrial bioenergetics in doxorubicin-induced cardiotoxicity and summarizes potential therapeutic interventions.

Cite This Study

Ling et al. (2022) conducted a review in Doxorubicin-induced cardiotoxicity. Chemical drugs and traditional herbal medicine was evaluated. This review summarizes the mechanisms of doxorubicin-induced cardiac mitochondrial bioenergetics disorders and potential interventions using chemical drugs and traditional herbal medicine.

synapsesocial.com/papers/6a7a4dcb5968508e56f3bc05https://doi.org/10.1155/2022/7176282
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Mitochondrial Determinants of Doxorubicin-Induced Cardiomyopathy2020 · 605 citations
  2. 2The Role of AMPK Activation for Cardioprotection in Doxorubicin-Induced Cardiotoxicity2020 · 190 citations
  3. 3Acute toxicity of doxorubicin on isolated perfused heart: response of kinases regulating energy supply2005 · 157 citations
  4. 4Doxorubicin Effect on Myocardial Metabolism as a Prerequisite for Subsequent Development of Cardiac Toxicity: A Translational <sup>18</sup>F-FDG PET/CT Observation2017 · 85 citations
  5. 5Honokiol, an activator of Sirtuin-3 (SIRT3) preserves mitochondria and protects the heart from doxorubicin-induced cardiomyopathy in mice2017 · 195 citations