Key result
Traditional Chinese medicine strategies targeting mitochondrial function are reviewed as potential approaches to prevent or reduce doxorubicin-induced cardiotoxicity.
Why the study?
Doxorubicin clinical efficacy is limited by cardiotoxicity, and the exact molecular mechanisms warrant further study alongside strategies such as traditional Chinese medicine to mitigate mitochondrial damage.
Does traditional Chinese medicine prevent or reduce doxorubicin-induced cardiotoxicity?
Does traditional Chinese medicine prevent or reduce doxorubicin-induced cardiotoxicity?
This review highlights the role of mitochondrial dysfunction in doxorubicin-induced cardiotoxicity and proposes traditional Chinese medicine as a potential preventive strategy.
May support mitochondrial-targeted cardioprotection during DOX therapy; leaves open specific pathway validation in clinical trials.
Doxorubicin (DOX), an anthracycline chemotherapeutic drug, is one of the most effective drugs for the treatment of various cancers. However, its therapeutic effect is seriously limited by related cardiotoxicity. Although this field has yielded many studies, the exact molecular mechanism of DOX-induced cardiotoxicity (DIC) is still worthy of further study. DOX is a mitochondrial toxin, and mitochondrial damage is the core of DIC. This paper reviews a large amount of literature and summarizes the mechanisms related to DIC that depend on mitochondrial dysfunction, including the effects of DOX on mitochondrial electron transport chain, redox cycle, oxidative stress, calcium imbalance, apoptosis pathway and mitophagy. In addition, it discusses the existing strategies of traditional Chinese medicine based on mitochondrial function to prevent and/or reduce DIC, to provide a scientific basis for combination of DOX and traditional Chinese medicine in the treatment of cancer.
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Wang et al. (2022) conducted a review in Doxorubicin-induced cardiotoxicity. Traditional Chinese medicine was evaluated. Traditional Chinese medicine strategies targeting mitochondrial function are reviewed as potential approaches to prevent or reduce doxorubicin-induced cardiotoxicity.
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