Key result
Mitochondria play a central role in doxorubicin-induced cardiotoxicity, and natural mitochondria-targeting compounds from Traditional Chinese Medicine offer potential adjunct or alternative treatments.
Why the study?
Doxorubicin-induced cardiotoxicity limits its clinical application, and emerging evidence highlights mitochondria as central to this toxicity, prompting interest in natural mitochondria-targeting Traditional Chinese Medicine compounds as alternative or adjunct treatments.
Mitochondria play a central role in doxorubicin-induced cardiotoxicity, and mitochondria-targeting compounds from Traditional Chinese Medicine offer potential adjunct or alternative treatments.
Hypothesis-generating for TCM mitochondria-targeting compounds in doxorubicin cardiotoxicity; prospective trials required before any clinical consideration.
Doxorubicin (DOX) is an antibiotic anthracycline extensively used in the treatment of different malignancies, such as breast cancer, lymphomas and leukemias. The cardiotoxicity induced by DOX is one of the most important pathophysiological events that limit its clinical application. Accumulating evidence highlights mitochondria as a central role in this process. Modulation of mitochondrial functions as therapeutic strategy for DOX-induced cardiotoxicity has thus attracted much attention. In particular, emerging studies investigated the potential of natural mitochondria-targeting compounds from Traditional Chinese Medicine (TCM) as adjunct or alternative treatment for DOX-induced toxicity. This review summarizes studies about the mechanisms of DOX-induced cardiotoxicity, evidencing the importance of mitochondria and presenting TCM treatment alternatives for DOX-induced cardiomyopathy.
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Souza et al. (2020) conducted a review in Doxorubicin-induced cardiotoxicity. Traditional Chinese Medicine (TCM) mitochondria-targeting compounds was evaluated. Mitochondria play a central role in doxorubicin-induced cardiotoxicity, and natural mitochondria-targeting compounds from Traditional Chinese Medicine offer potential adjunct or alternative treatments.
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