Key result
Traditional Chinese medicine monomers and compounds show potential in preventing and treating doxorubicin-induced cardiotoxicity by modulating oxidative stress, apoptosis, and inflammation pathways.
Why the study?
Doxorubicin is a widely used antitumor drug, but its clinical utility is limited by cardiotoxicity.
This review outlines the molecular mechanisms of doxorubicin-induced cardiotoxicity and suggests that Traditional Chinese Medicine may offer novel therapeutic strategies for its prevention and treatment.
TCM strategies for doxorubicin cardiotoxicity remain hypothesis-generating; leaves open randomized validation before any clinical consideration.
Doxorubicin is a widely used antitumor drug, but its cardiotoxicity limits its clinical use. This paper reviews the main mechanisms of Doxorubicin causing cardiotoxicity, including topoisomerase IIβ, oxidative stress, mitochondrial function, calcium homeostasis, autophagy, and apoptosis, etc. It also introduces some novel targets and strategies, such as the CRTH2 receptor, the Nrf2 signaling pathway, the SIRTs family of proteins, and the progress of the research on the treatment of traditional Chinese medicine. This paper aims to provide new ideas and directions for the prevention and treatment of Doxorubicin cardiotoxicity.
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Li et al. (2024) conducted a review in Doxorubicin-induced cardiotoxicity. Traditional Chinese Medicine was evaluated. Traditional Chinese medicine monomers and compounds show potential in preventing and treating doxorubicin-induced cardiotoxicity by modulating oxidative stress, apoptosis, and inflammation pathways.
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