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August 7, 2025Annals of HematologyOpen Access

“In situ” MYC rearrangement and amplification as a secondary change in a case of High-grade B cell lymphoma with 11q aberration

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Authors

GSGioia Di StefanoSBSusanne BensAFAnja Fischer

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Overview

Case report reveals MYC rearrangement as a secondary event in high-grade B cell lymphoma with 11q aberration, implying new classification considerations.

Key Points

  • MYC rearrangement is usually considered absent in high-grade B cell lymphoma with 11q aberration.
  • This case shows MYC rearrangement occurring as a secondary change in a patient with aggressive lymphoma.
  • High-grade B cell lymphoma exhibits specific cytogenetic alterations on chromosome 11, such as copy number gains.
  • Understanding MYC rearrangement implications may change how high-grade B cell lymphomas are classified and treated.

Cite This Study

Stefano et al. (2025) studied this question.

synapsesocial.com/papers/689dfe88d61984b91e13b746https://doi.org/10.1007/s00277-025-06433-8
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Novel case of cytoplasmic CD3 positive, surface CD4 positive high-grade B-cell lymphoma with MYC rearrangement2026
  2. 2High-grade B-cell lymphoma with 11q aberration in the HIV setting: a clinicopathological study of 10 cases and literature review2024
  3. 3Clinical outcomes, patterns of relapse and molecular landscape of advanced stage High Grade B-cell Lymphoma2026
  4. 4Abstract P35: High-grade B-cell lymphomas with 11q aberrations show a dark zone expression profile similar to Burkitt lymphoma but with additional extension towards intermediate germinal center B-cells2024
  5. 5Evaluation of Immunohistochemical Expression of C-MYC, BCL2, and BCL6 in High Grade B-cell Lymphoma2026