What does this research mean for the field?

High-grade B-cell lymphoma with MYC rearrangement can exhibit aberrant cytoplasmic CD3 and surface CD4 expression, potentially leading to misdiagnosis as a T-cell lymphoma. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To describe a novel presentation of high-grade B-cell lymphoma displaying aberrant cytoplasmic CD3 and surface CD4 expression alongside a MYC rearrangement.

August 30, 2026Journal of HematopathologyOpen Access

Novel case of cytoplasmic CD3 positive, surface CD4 positive high-grade B-cell lymphoma with MYC rearrangement

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Authors

VMVladimir Miltchev NGNatalia Golardi

Discussion

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Overview

Case report demonstrates aberrant T-cell marker expression in high-grade B-cell lymphoma, highlighting the need for thorough lineage evaluation to avoid misdiagnosis.

Key Points

To describe a novel presentation of high-grade B-cell lymphoma displaying aberrant cytoplasmic CD3 and surface CD4 expression alongside a MYC rearrangement.
Evaluated a 50-year-old male with central nervous system symptoms, a persistent bladder mass, and a prior diagnosis of peripheral T-cell lymphoma.
Performed diagnostic workup via bladder biopsy, cerebrospinal fluid flow cytometry, immunohistochemical staining, and fluorescence in situ hybridization (FISH).
Flow cytometry and histology demonstrated a clonal high-grade B-cell neoplasm positive for CD10, CD79a, PAX5, patchy CD20, and lambda light chain, with anomalous cytoplasmic CD3 and dim surface CD4 expression.
FISH analysis identified a t(8;14)(q24;q32) MYC::IGH rearrangement with no evidence of BCL2 or BCL6 rearrangements.

Cite This Study

Miltchev et al. (2026) studied this question.

synapsesocial.com/papers/6a93f00a6c1a8fb52e79c121 https://doi.org/10.1007/s12308-026-00728-z

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August 30, 2026Journal of HematopathologyOpen Access

Novel case of cytoplasmic CD3 positive, surface CD4 positive high-grade B-cell lymphoma with MYC rearrangement

View Full Paper

Ask AI

Bookmark

Authors

VMVladimir Miltchev NGNatalia Golardi

Discussion

Member takes

Overview

Case report demonstrates aberrant T-cell marker expression in high-grade B-cell lymphoma, highlighting the need for thorough lineage evaluation to avoid misdiagnosis.

Key Points

To describe a novel presentation of high-grade B-cell lymphoma displaying aberrant cytoplasmic CD3 and surface CD4 expression alongside a MYC rearrangement.
Evaluated a 50-year-old male with central nervous system symptoms, a persistent bladder mass, and a prior diagnosis of peripheral T-cell lymphoma.
Performed diagnostic workup via bladder biopsy, cerebrospinal fluid flow cytometry, immunohistochemical staining, and fluorescence in situ hybridization (FISH).
Flow cytometry and histology demonstrated a clonal high-grade B-cell neoplasm positive for CD10, CD79a, PAX5, patchy CD20, and lambda light chain, with anomalous cytoplasmic CD3 and dim surface CD4 expression.
FISH analysis identified a t(8;14)(q24;q32) MYC::IGH rearrangement with no evidence of BCL2 or BCL6 rearrangements.

Cite This Study

Miltchev et al. (2026) studied this question.

synapsesocial.com/papers/6a93f00a6c1a8fb52e79c121 https://doi.org/10.1007/s12308-026-00728-z

Also Consider

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