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Palladium-catalyzed reaction produces enynes from thioesters, highlighting its utility in drug synthesis.
A palladium-catalyzed ligand-controlled acyl and decarbonylative Sonogashira reaction of alkenyl thioesters with terminal alkynes was developed. 1,3-Enynes and enynone products were obtained by using 1,3-bis(diphenylphosphino)propane and P(3,5-(CF3)2C6H3)3 as the ligands, respectively. To demonstrate the synthetic utilities, late-stage constructions of 1,3-enyne and enynone skeletons in natural products and drugs were showcased.
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Sun et al. (2025) studied this question.
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