August 7, 2025Discover OncologyOpen Access

Causal relationship among immune cells, basal cell carcinoma, and gut microbiome: a two-sample Mendelian randomization analysis and mediation analysis

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Discussion

Mendelian randomization shows gut microbiome influences basal cell carcinoma via immune cells, suggesting potential therapies.

The research identifies a causal relationship between gut microbiome and basal cell carcinoma risk.
Mendelian randomization used data from a genome-wide association study involving European ancestry.
Nine genera and 47 immune cell traits were found to be genetically linked to basal cell carcinoma.
Findings may inform new therapeutic and preventative approaches for basal cell carcinoma.

Li et al. (2025) studied this question.

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