August 9, 2025

Comprehensive molecular characterization of Rho GTPases and their regulators across human cancers.

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Authors

SLShangyi LuoFujian Medical University SQShupei QiaoHarbin Medical University LLLi LiuNanjing Agricultural University

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Implication

Comprehensive assessment of rho gtpases and their regulators reveals significant survival outcomes in cancer patients, indicating potential targets for treatment.

Key Points

This research highlights the dysregulation of rho gtpases and their regulators across 33 cancer types.
Nineteen driver genes were identified with significant somatic mutations linked to cancer progression.
Unsupervised clustering revealed six subtypes of rho gtpase regulation, each correlated with distinct patient outcomes.
Findings emphasize the relevance of rho gtpases in cancer development and potential for targeted therapies.

Cite This Study

Luo et al. (2025) studied this question.

synapsesocial.com/papers/689dfea6d61984b91e13c877 https://doi.org/10.1002/ijc.70077

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Implication

Comprehensive assessment of rho gtpases and their regulators reveals significant survival outcomes in cancer patients, indicating potential targets for treatment.

Comprehensive molecular characterization of Rho GTPases and their regulators across human cancers.

Discussion

Member takes

Implication

Key Points

Cite This Study

Comprehensive molecular characterization of Rho GTPases and their regulators across human cancers.

Discussion

Member takes

Implication

Key Points

Cite This Study

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