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September 10, 2025Translational Andrology and UrologyOpen Access

RhoJ promotes the progression of clear cell renal cell carcinoma via the TNF-α/NF-κB axis

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Authors

JFJ. FengBZBin ZhengJWJichen Wang

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Overview

This analysis evaluates RhoJ's expression in clear cell renal cell carcinoma, suggesting it plays a crucial role in tumor progression via the TNF-α/NF-κB pathway.

Key Points

  • RhoJ expression significantly correlates with poor prognosis in clear cell renal cell carcinoma patients.
  • Inhibiting RhoJ decreased tumor growth and mitigated aggressive cancer traits like migration and invasion.
  • The study identified drugs targeting RhoJ that may provide new treatments for clear cell renal cell carcinoma.
  • The TNF-α/NF-κB pathway facilitates RhoJ-driven ccRCC progression, highlighting a potential therapeutic target.

Cite This Study

Feng et al. (2025) studied this question.

synapsesocial.com/papers/68c1a13a54b1d3bfb60dcc1ehttps://doi.org/10.21037/tau-2025-132
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