August 12, 2025

Characterization of Breakthrough Hemolysis in Patients With Paroxysmal Nocturnal Hemoglobinuria: An International Multicenter Experience.

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Discussion

Observational research found 51% of PNH patients experienced breakthrough hemolysis, suggesting a need for standardized management of complications.

BTH occurs in 51% of patients with PNH on complement inhibitors, with 271 events noted.
Severe BTH in about half required interventions such as transfusions or dosing adjustments.
The incidence rate of BTH was 0.19 events per patient-year, higher with proximal inhibitors.
Predictors of BTH include severe disease at diagnosis and treatment with proximal inhibitors.

Fattizzo et al. (2025) studied this question.

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Observational research found 51% of PNH patients experienced breakthrough hemolysis, suggesting a need for standardized management of complications.