Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
December 8, 2025BloodOpen Access

The effect of breakthrough hemolysis on complement factor h and factor I levels in paroxysmal nocturnal hemoglobinuria

View Full Paper
Ask AI
Bookmark
Share

Authors

DPDaniel PaynePMPetra Muus

Discussion

Loading...

Member takes

Overview

Observations showed elevated complement factor h levels during breakthrough hemolysis in paroxysmal nocturnal hemoglobinuria, indicating possible regulatory mechanisms.

Key Points

  • This research explores how levels of complement factor h vary in patients with paroxysmal nocturnal hemoglobinuria during breakthrough hemolysis.
  • Blood samples collected from 61 patients with PNH during routine visits.
  • Patients grouped by treatment status during sampling; levels measured during breakthrough hemolysis events.
  • Complement factor h and factor I levels assessed using sandwich ELISA.
  • Complement factor h levels significantly higher during breakthrough hemolysis compared to untreated patients.
  • No significant change in complement factor I levels during breakthrough hemolysis.
  • Baseline complement factor I levels were lower in patients with a history of breakthrough hemolysis.

Cite This Study

Payne et al. (2025) studied this question.

synapsesocial.com/papers/69362f764fa91c937236e404https://doi.org/10.1182/blood-2025-3193
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Factor bb as a biomarker during breakthrough hemolysis in paroxysmal nocturnal hemoglobinuria2025
  2. 2Real-world data on breakthrough hemolysis in patients with paroxysmal nocturnal hemoglobinuria treated with proximal and terminal complement inhibitors.2025
  3. 3Real-world breakthrough hemolysis patterns across 1,723 patient-years of complement inhibition in paroxysmal nocturnal hemoglobinuria2025
  4. 4Characterization of Breakthrough Hemolysis in Patients With Paroxysmal Nocturnal Hemoglobinuria: An International Multicenter Experience.2025 · 6 citations
  5. 5The role of red blood cell lifespan in evaluating the condition of patients with paroxysmal nocturnal hemoglobinuria treated with complement inhibitors2025