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August 13, 2025

Endometrial Mesonephric-Like Carcinoma With Prominent Clear Cell Carcinoma-Like Features.

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Authors

MGMaría Fernanda Gómez-ValenciaNPNicholas J. ProtopsaltisUC San Diego Health SystemWSWei SongUC San Diego Health System

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Implication

This analysis reveals significant similarities between endometrial mesonephric-like and clear cell carcinoma, suggesting potential misclassification.

Key Points

  • Endometrial mesonephric-like carcinoma exhibited prominent clear cell carcinoma-like features in 40% of the sample.
  • Both components showed similar nuclear features and immunoreactivity patterns, indicating morphological mimicry.
  • Next generation sequencing revealed the same KRAS G12V variant in both tumor components, suggesting shared origins.
  • This case underscores the risk of misclassifying endometrial tumors due to striking similarities in morphology.

Cite This Study

Gómez-Valencia et al. (2025) studied this question.

synapsesocial.com/papers/689e03e9d61984b91e13d30fhttps://doi.org/10.1177/10668969251361180
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Identifying mesonephric‐like adenocarcinoma of the endometrium by combining SOX17 and PAX8 immunohistochemistry2024 · 14 citations
  2. 2SOX17 expression in mesonephric‐like adenocarcinomas and mesonephric remnants/hyperplasia of the female genital tract: Expanding its utility as a Müllerian biomarker2024 · 8 citations
  3. 3Napsin-A Expression in Mesonephric and Mesonephric-like Adenocarcinomas: Implications for Distinction From Clear Cell Carcinoma2025 · 6 citations
  4. 4Frequent Expression of Napsin A in Clear Cell Carcinoma of the Endometrium2013 · 97 citations
  5. 5Papillary and ductal patterns of mesonephric‐like adenocarcinomas are often overlooked: a retrospective revaluation of over 1000 endometrial carcinomas2024 · 5 citations