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November 1, 2025American Journal of Clinical PathologyOpen Access

77 Advanced-Stage Uterine Mesonephric-Like Adenocarcinoma Without Endometrial Involvement: A Diagnostic Challenge

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Authors

SGSwati GiteNTnidhi tandonPTParul Tanwar

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Overview

Case report reveals metastatic carcinoma in a 75-year-old woman, suggesting complexity in diagnosis and management.

Key Points

  • To present a rare case of mesonephric-like adenocarcinoma without endometrial involvement.
  • Case report of a 75-year-old woman
  • Initial presentation with abdominal pain and imaging showing masses and lymphadenopathy
  • Biopsy and subsequent surgical excision with histology and immunohistochemical studies
  • Diagnosis confirmed as mesonephric-like adenocarcinoma involving myometrium and adenomyosis
  • Histology showed positivity for PAX8, with negative estrogen and progesterone receptors
  • Surgical findings indicated metastatic carcinoma in the ovary

Cite This Study

Gite et al. (2025) studied this question.

synapsesocial.com/papers/69254371c0ce034ddc3587aehttps://doi.org/10.1093/ajcp/aqaf121.173
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Mesonephric-Like Adenocarcinoma of the Endometrium: A Rare and Diagnostically Challenging Entity2026
  2. 2Peritoneal Mesonephric-Like Adenocarcinoma Arising in Endometriosis: Case Report and Review of the Literature Expanding the Spectrum of Extrauterine Mesonephric-Like Adenocarcinomas2026
  3. 3Expanded Histologic Lineage and Origin of Mesonephric-Like Adenocarcinoma: A Clinicopathologic Study of 9 Cases2025 · 1 citations
  4. 4Case Report: Hormone receptor-positive uterine mesonephric-like adenocarcinoma2026
  5. 5Mesonephric-like Adenocarcinoma (MLA) Diagnostic Criteria and Controversies: Perspectives and Guidance From Pathologists in the MLA Consortium2025