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August 14, 2025

N-acetylcysteine Efficacy on Cocaine Base Paste Use Disorder: A Randomized Double-blind Placebo-controlled Clinical Trial.

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Authors

CBCarmen Betancur-MorenoEMEsteban Moraga-EscobarCGCarolina Gómez‐Llorente

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Overview

Randomized trial tested n-acetylcysteine for abstinence in cocaine base paste use disorder, indicating prior abstinence may enhance its efficacy.

Key Points

  • N-acetylcysteine was tested for its ability to prolong abstinence in adults with cocaine base paste use disorder.
  • Participants were followed for 4 weeks, with statistical analysis revealing no significant difference compared to placebo (P = 0.12).
  • Subgroup analysis showed a positive impact of NAC in those with more than 7 days of prior abstinence (P = 0.0052).
  • These findings suggest that prior abstinence influences the efficacy of NAC for relapse prevention in use disorder.

Cite This Study

Betancur-Moreno et al. (2025) studied this question.

synapsesocial.com/papers/689fc6852abb084d53ed237chttps://doi.org/10.1097/adm.0000000000001561
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1A single extinction-based treatment with N-Acetylcysteine produces long-term reduction in cocaine relapse2026
  2. 2An evaluation of N-acetylcysteine in a sequential oxycodone and cocaine rat self-administration model.2026
  3. 3The Role of Twice-Daily N-acetylcysteine (NAC) 2400 mg in Smoking Cessation: A Randomized, Placebo-Controlled Trial in Indonesia2024 · 3 citations
  4. 4N-acetylcysteine as a treatment for substance use cravings: A meta-analysis2024
  5. 5N-acetyl cysteine for the treatment of alcohol use disorder: study protocol for a multi-site, double-blind randomised controlled trial (NAC-AUD study)2025