Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
March 21, 2026Translational PsychiatryOpen Access

A single extinction-based treatment with N-Acetylcysteine produces long-term reduction in cocaine relapse

View Full Paper
Ask AI
Bookmark
Share

Authors

SHShuo HuangSoutheast UniversityZSZhihao SongCentral South UniversityCSCuijie ShiHebei Medical University

Discussion

Loading...

Member takes

Implication

Investigating N-acetylcysteine's role in reducing relapse among cocaine-dependent rats, suggesting a promising treatment approach.

Key Points

  • This research aims to assess the efficacy of a single dose of N-acetylcysteine in reducing cocaine-seeking behavior post-extinction training.
  • Utilized a self-administration model for cocaine addiction in rats.
  • Conducted a 7-day abstinence period before administering a single NAC dose.
  • Evaluated cocaine-seeking behavior during extinction training and reinstatement tests.
  • Administered the mGlu2/3 antagonist to analyze the mechanism of NAC's effects.
  • NAC significantly reduced cocaine-seeking behavior on the first day of extinction training.
  • Effects of NAC lasted for at least 28 days post-treatment.
  • Mglu2/3 antagonist blocked the enduring effects of NAC on reinstatement tests.
  • NAC also reduced context-induced reinstatement of cocaine-seeking behavior.

Cite This Study

Huang et al. (2026) studied this question.

synapsesocial.com/papers/69be371c6e48c4981c676837https://doi.org/10.1038/s41398-026-03954-2
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1N-acetylcysteine in substance use disorder: a lesson from preclinical and clinical research2021 · 30 citations
  2. 2Renewal of drug seeking by contextual cues after prolonged extinction in rats.2002 · 387 citations
  3. 3The antioxidants α‐lipoic acid and N ‐acetylcysteine reverse memory impairment and brain oxidative stress in aged SAMP8 mice2003 · 463 citations
  4. 4Glutamate transporter GLT ‐1 mediates N ‐acetylcysteine inhibition of cocaine reinstatement2014 · 185 citations