Novel nanocomposites demonstrate improved antimicrobial activity against Staphylococcus aureus, indicating potential for tailored wound care.
This study introduces novel nanocomposites incorporating Brazilian red propolis (RPNP) into acrylic resins, designed for advanced wound dressing applications. The nanocomposites exhibit enhanced mechanical properties, including increased flexibility and reduced elastic modulus, along with potent antimicrobial activity, particularly against Staphylococcus aureus . The ability to customize drug release profiles—tuning the polymeric compounds of the nanocomposite—offers versatile treatment options for various wound conditions. Spectroscopic and FTIR analyses confirmed the presence of bioactive phenolic compounds, such as naringenin, which contributes to the antimicrobial efficacy of the materials. Additionally, Two‐Photon Polymerization enabled the creation of customizable microarchitectures, supporting cell adhesion, proliferation, and differentiation, further promoting wound healing. These features, coupled with the bioactivity of Brazilian red propolis, position the nanocomposites as promising platforms for wound care, combining infection control with enhanced healing. Future research will focus on clinical trials and the further refinement of these materials for broader biomedical applications.
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Santos et al. (2025) studied this question.
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