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May 2, 2024

Synergistic nanocoating: Layer-by-Layer functionalised PCL membranes enhanced with manuka honey and essential oils for advanced wound healing

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Authors

CGCamilla GalloJGJoel Girón‐HernándezDHDaisy A. Honey

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Overview

Experimental study demonstrates enhanced antimicrobial activity and healing gene expression in fibroblast cell cultures, highlighting potential utility for chronic wound dressings.

Key Points

  • Polycaprolactone membranes coated with manuka honey and essential oils nanoemulsions exhibited potent antibacterial activity against common wound pathogens.
  • Chronic wounds impact 1–2% of developed nation populations, while modified electrospinning scaffolds successfully upregulated VEGF and COL1 reparative genes.
  • Electrospinning technique and Layer-by-Layer assembly functionalised the bioactive meshes, confirming safety in a fibroblast cells model although in vivo testing is still needed.

Cite This Study

Gallo et al. (2024) studied this question.

synapsesocial.com/papers/68e6bd3bb6db64358763d5efhttps://doi.org/10.21203/rs.3.rs-4219367/v1
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