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June 12, 2026Journal of Biomaterials Science Polymer Edition

Polydopamine/gelatin layer-by-layer self-assembled polycaprolactone nanofibers loaded with 4-methoxycinnamic acid for wound healing

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Authors

KSKumar ShivaneeRSRajan Kalpana SahanaABArumugam Bharathraj

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Overview

Randomized trial demonstrates enhanced wound healing in fibroblast cells, indicating promising applications for difficult wounds.

Key Points

  • The study aims to develop a novel wound dressing using MCA-loaded polycaprolactone nanofibers to improve healing properties.
  • Developed MCA-loaded polycaprolactone nanofibers with layer-by-layer self-assembly of polydopamine and gelatin.
  • Conducted physicochemical and morphological analyses to assess structural integrity.
  • Evaluated biocompatibility using fibroblast cell assays to measure attachment, proliferation, and migration.
  • The fabricated nanofibers showed improved cell attachment and enhanced expression of angiogenic and fibrotic genes.
  • Demonstrated significant antioxidant activity and anti-inflammatory effects.
  • Exhibited potent antibacterial properties against infection-causing microbes.

Cite This Study

Shivanee et al. (2026) studied this question.

synapsesocial.com/papers/6a2ba2f68101cf8926f01b8bhttps://doi.org/10.1080/09205063.2026.2683525
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