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This research investigates the potential of Croton macrostachyus leaf extract as a wound dressing by integrating it into nanofibers.

Croton Macrostachyus Leaf Extract Loaded Nanofibers for Potential Wound Dressings

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Randomized trial reveals enhanced antibacterial and wound healing properties in advanced dressings using Croton macrostachyus extract.

This research investigates the potential of Croton macrostachyus leaf extract as a wound dressing by integrating it into nanofibers.
Electrospinning was used to integrate Croton macrostachyus leaf extract into polycaprolactone-cellulose acetate nanofibers.
Morphological, thermal, and mechanical properties were analyzed, along with in vitro evaluations of antibacterial efficacy and cell viability.
Cell migration, hydrophilicity, and swelling capacity were assessed to evaluate wound healing potential.
PCL–CA–CM nanofibers showed fiber diameters of 326 ± 85 nm to 374 ± 92 nm and 61–80% porosity.
Significant antibacterial activity was recorded, reducing S. aureus by 66.77–99% and E. coli by 58.18–99%.
Cell viability exceeded 70%, demonstrating minimal cytotoxicity, while enhancements in hydrophilicity, swelling capacity, and mechanical strength were observed.

Adamu et al. (2026) studied this question.

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View Full Paper

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Authors

Randomized trial reveals enhanced antibacterial and wound healing properties in advanced dressings using Croton macrostachyus extract.

This research investigates the potential of Croton macrostachyus leaf extract as a wound dressing by integrating it into nanofibers.
Electrospinning was used to integrate Croton macrostachyus leaf extract into polycaprolactone-cellulose acetate nanofibers.
Morphological, thermal, and mechanical properties were analyzed, along with in vitro evaluations of antibacterial efficacy and cell viability.
Cell migration, hydrophilicity, and swelling capacity were assessed to evaluate wound healing potential.
PCL–CA–CM nanofibers showed fiber diameters of 326 ± 85 nm to 374 ± 92 nm and 61–80% porosity.
Significant antibacterial activity was recorded, reducing S. aureus by 66.77–99% and E. coli by 58.18–99%.
Cell viability exceeded 70%, demonstrating minimal cytotoxicity, while enhancements in hydrophilicity, swelling capacity, and mechanical strength were observed.

Adamu et al. (2026) studied this question.

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