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May 24, 2026Drug Delivery and Translational ResearchOpen Access

Accelerating wound healing rates with Cucurbita pepo leaf extract loaded electrospun poly(methyl methacrylate)/Halloysite/Chitosan/CaCO₃ composite nanofibers through in vitro and in vivo assessments

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Authors

EAEsraa B. AbdelazimSAShaza H. AlySEShahira H. EL-Moslamy

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Overview

Randomized trial shows enhanced wound healing with Cucurbita pepo extract-loaded nanofibers, suggesting new treatment options.

Key Points

  • To assess the effectiveness of Cucurbita pepo leaf extract incorporated into composite nanofibers in accelerating wound healing rates.
  • Developed PMMA/Hal/CS/CaCO₃ composite nanofibers via electrospinning with Cucurbita pepo leaf extract.
  • Conducted in vitro assays including agar well-diffusion and antibiofilm testing.
  • Performed in vivo evaluations monitoring healing rates and histological analysis over 14 days.
  • Achieved a 99.9% wound healing rate by day 14 with CPE-loaded nanofibers.
  • Histological analysis indicated increased macrophage infiltration, neovascularization, and fibroblast proliferation by day 7.
  • Demonstrated significant antimicrobial activity against wound-associated pathogens.

Cite This Study

Abdelazim et al. (2026) studied this question.

synapsesocial.com/papers/6a12965848a0ea16656730fehttps://doi.org/10.1007/s13346-026-02124-7
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