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April 8, 2021Journal of Applied Polymer Science

Electrospun polylactic acid nanofiber membranes containing Capparis spinosa L. extracts for potential wound dressing applications

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Authors

PZPeng ZhuZhengzhou UniversityXZXingqun ZhangSinopec (China)YWYunlong WangHeilongjiang University of Technology

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Implication

In vitro study demonstrates enhanced antibacterial and antioxidant performance in polylactic acid nanofiber membranes loaded with Capparis spinosa, suggesting potential utility as wound dressings.

Key Points

  • To develop and evaluate electrospun polylactic acid nanofiber membranes loaded with Capparis spinosa L. extract for active wound dressing applications.
  • Fabricated composite nanofiber membranes of polylactic acid (PLA) incorporating 0, 4, 7, and 10 wt% Capparis spinosa L. (CSL) ethyl acetate extract via electrospinning.
  • Characterized fiber morphology, chemical functional groups, surface wettability via water contact angle, and in vitro drug release dynamics over time.
  • Evaluated antioxidant resistance and antibacterial efficacy against Escherichia coli and Staphylococcus aureus across different CSL extract concentrations.
  • Incorporation of CSL reduced nanofiber diameter, increased hydrophilicity, and enhanced membrane antioxidant resistance.
  • Drug release profiles exhibited a burst release during the initial 12 hours followed by sustained, slow release over an extended period.
  • Nanofiber antibacterial activity against Escherichia coli and Staphylococcus aureus increased in a concentration-dependent manner with increasing CSL loading.

Cite This Study

Zhu et al. (2021) studied this question.

synapsesocial.com/papers/6aa63a5a66012019823a5adbhttps://doi.org/10.1002/app.50800
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