What question did this study set out to answer?

To develop and characterize needleless emulsion electrospun PCL/PVA_PEC nanofibrous meshes loaded with Chelidonium majus extract for antibacterial wound dressing applications.

July 9, 2021NanomaterialsOpen Access

Chelidoniummajus L. Incorporated Emulsion Electrospun PCL/PVAPEC Nanofibrous Meshes for Antibacterial Wound Dressing Applications

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Authors

CMClaúdia MouroUniversity of Beira Interior AGAna P. GomesUniversity of Beira Interior MAMerja AhonenSatakunta University of Applied Sciences

Discussion

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Implication

In vitro study demonstrates bacterial inhibition by Chelidonium majus-loaded electrospun meshes without cytotoxicity, suggesting potential for advanced infection-resistant wound dressings.

Key Points

To develop and characterize needleless emulsion electrospun PCL/PVA_PEC nanofibrous meshes loaded with Chelidonium majus extract for antibacterial wound dressing applications.
Fabricated polycaprolactone/polyvinyl alcohol_pectin (PCL/PVA_PEC) nanofibrous meshes incorporating Chelidonium majus extract via needleless emulsion electrospinning.
Evaluated mesh fiber morphology in comparison to the skin's extracellular matrix, controlled release properties, antibacterial activity against S. aureus and P. aeruginosa, and cytotoxicity in normal human dermal fibroblasts (NHDF).
The electrospun PCL/PVA_PEC meshes replicated the morphological architecture of the natural skin extracellular matrix and enabled controlled release of the plant extract.
Chelidonium majus-loaded meshes achieved up to a 3.82 Log reduction in Staphylococcus aureus and Pseudomonas aeruginosa growth while showing no cytotoxic effects on normal human dermal fibroblasts.

Cite This Study

Mouro et al. (2021) studied this question.

synapsesocial.com/papers/6a99cc850d1af6986aabfd38 https://doi.org/10.3390/nano11071785

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July 9, 2021NanomaterialsOpen Access

Chelidoniummajus L. Incorporated Emulsion Electrospun PCL/PVAPEC Nanofibrous Meshes for Antibacterial Wound Dressing Applications

View Full Paper

Ask AI

Bookmark

Authors

CMClaúdia MouroUniversity of Beira Interior AGAna P. GomesUniversity of Beira Interior MAMerja AhonenSatakunta University of Applied Sciences

Discussion

Member takes

Implication

In vitro study demonstrates bacterial inhibition by Chelidonium majus-loaded electrospun meshes without cytotoxicity, suggesting potential for advanced infection-resistant wound dressings.

Key Points

To develop and characterize needleless emulsion electrospun PCL/PVA_PEC nanofibrous meshes loaded with Chelidonium majus extract for antibacterial wound dressing applications.
Fabricated polycaprolactone/polyvinyl alcohol_pectin (PCL/PVA_PEC) nanofibrous meshes incorporating Chelidonium majus extract via needleless emulsion electrospinning.
Evaluated mesh fiber morphology in comparison to the skin's extracellular matrix, controlled release properties, antibacterial activity against S. aureus and P. aeruginosa, and cytotoxicity in normal human dermal fibroblasts (NHDF).
The electrospun PCL/PVA_PEC meshes replicated the morphological architecture of the natural skin extracellular matrix and enabled controlled release of the plant extract.
Chelidonium majus-loaded meshes achieved up to a 3.82 Log reduction in Staphylococcus aureus and Pseudomonas aeruginosa growth while showing no cytotoxic effects on normal human dermal fibroblasts.

Cite This Study

Mouro et al. (2021) studied this question.

synapsesocial.com/papers/6a99cc850d1af6986aabfd38 https://doi.org/10.3390/nano11071785

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