Iridium-catalyzed diborylation improves regioselectivity in heterobiaryls, suggesting efficiency in synthesis.
The expedient iridium‐catalyzed diborylation of 2‐aryl pyridines and isoquinolines with bis(pinacolato)diboron (B 2 pin 2 ) is reported. Utilizing [Ir(OMe)(COD)] 2 and a terpyridine derivate as tridentate ligand, which are rarely used for directed C─H borylation, the heterobiaryls were selectively diborylated in the 2,6‐position of the carbocycle. The developed method shows exceptional high activity as well as regioselectivity with low catalyst loading.
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Stehrer et al. (2025) studied this question.
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